Bisphosphonate-related osteonecrosis of the jaws: analysis of a case series at a dental school.
Identifieur interne : 000196 ( Main/Exploration ); précédent : 000195; suivant : 000197Bisphosphonate-related osteonecrosis of the jaws: analysis of a case series at a dental school.
Auteurs : Luiz Fernando Scalli Mathias Duarte ; Heitor Batista Dos Reis ; Renata Tucci ; Luciano Lauria DibSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 1754-4505 ]
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Brésil (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Ostéonécrose de la mâchoire associée aux biphosphonates (chirurgie), Ostéonécrose de la mâchoire associée aux biphosphonates (diagnostic), Ostéonécrose de la mâchoire associée aux biphosphonates (épidémiologie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), École dentaire (MeSH), Études rétrospectives (MeSH).
- MESH :
- chirurgie : Ostéonécrose de la mâchoire associée aux biphosphonates.
- diagnostic : Ostéonécrose de la mâchoire associée aux biphosphonates.
- épidémiologie : Brésil, Ostéonécrose de la mâchoire associée aux biphosphonates.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, École dentaire, Études rétrospectives.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Bisphosphonate-Associated Osteonecrosis of the Jaw (diagnosis), Bisphosphonate-Associated Osteonecrosis of the Jaw (epidemiology), Bisphosphonate-Associated Osteonecrosis of the Jaw (surgery), Brazil (epidemiology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Schools, Dental (MeSH), Treatment Outcome (MeSH).
- MESH :
- geographic , epidemiology : Brazil.
- diagnosis : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- epidemiology : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- surgery : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Schools, Dental, Treatment Outcome.
Abstract
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an adverse effect of drugs used to treat bone metabolism diseases, such as osteoporosis and bone metastases. The present study retrospectively evaluated the clinical characteristics and evolution of BRONJ cases that were diagnosed and treated at a dental school from 2004 to 2011. During that period, 13 patients met the criteria of the study among a population of 2,342 patients with oral lesions. Of the 13 patients, 12 were females. Ten were intravenous bisphosphonate users, and nine had breast cancer as the primary disease. Eight mandibular cases were observed. Eight patients interrupted the use of the bisphosphonates temporarily during the treatment. Surgical treatment was conducted in 10 patients, which was associated with platelet-rich plasma in six cases, which led to a regression to Stage I in 50% of these and cure in 33.3%. Of the total sample, four (30.8%) cases were cured, six (46.1%) regressed to Stage I, and three (23.1%) remained in Stage II after treatment. Dental rehabilitation occurred in seven patients. Dissemination of knowledge among professionals is essential for prevention and early diagnosis of BRONJ. Dental schools must act as reference centers and participate in the multidisciplinary care of bisphosphonate users.
DOI: 10.1111/scd.12023
PubMed: 23875734
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Dos Reis, Heitor Batista" sort="Dos Reis, Heitor Batista" uniqKey="Dos Reis H" first="Heitor Batista" last="Dos Reis">Heitor Batista Dos Reis</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
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<term>Bisphosphonate-Associated Osteonecrosis of the Jaw (epidemiology)</term>
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<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en">Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an adverse effect of drugs used to treat bone metabolism diseases, such as osteoporosis and bone metastases. The present study retrospectively evaluated the clinical characteristics and evolution of BRONJ cases that were diagnosed and treated at a dental school from 2004 to 2011. During that period, 13 patients met the criteria of the study among a population of 2,342 patients with oral lesions. Of the 13 patients, 12 were females. Ten were intravenous bisphosphonate users, and nine had breast cancer as the primary disease. Eight mandibular cases were observed. Eight patients interrupted the use of the bisphosphonates temporarily during the treatment. Surgical treatment was conducted in 10 patients, which was associated with platelet-rich plasma in six cases, which led to a regression to Stage I in 50% of these and cure in 33.3%. Of the total sample, four (30.8%) cases were cured, six (46.1%) regressed to Stage I, and three (23.1%) remained in Stage II after treatment. Dental rehabilitation occurred in seven patients. Dissemination of knowledge among professionals is essential for prevention and early diagnosis of BRONJ. Dental schools must act as reference centers and participate in the multidisciplinary care of bisphosphonate users.</div>
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<name sortKey="Mathias Duarte, Luiz Fernando Scalli" sort="Mathias Duarte, Luiz Fernando Scalli" uniqKey="Mathias Duarte L" first="Luiz Fernando Scalli" last="Mathias Duarte">Luiz Fernando Scalli Mathias Duarte</name>
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